Casarett & Doull's Essentials of Toxicology by Curtis Klaassen & John B. Watkins III

Author:Curtis Klaassen & John B. Watkins III
Language: eng
Format: epub
Publisher: McGraw-Hill Education
Published: 2010-11-15T00:00:00+00:00

Pyridinethione—

Zinc pyridinethione has antibacterial and antifungal properties and is a component of shampoos that are effective in the treatment of seborrhea and dandruff. Only the pyridinethione moiety is absorbed following ingestion, with the majority of zinc eliminated in the feces. Pyridinethione appears to interfere with the fast axonal transport systems, impairs the turnaround of rapidly transported vesicles, and slows the retrograde transport of vesicles. Aberration of the fast axonal transport systems most likely contributes to the accumulation of tubular and vesicular structures in the distal axon (Figure 16–6). As these materials accumulate in one region of the axon, the axon degenerates in its more distal regions beyond the accumulated structures. The earliest signs are diminished grip strength and changes of the axon terminal, leading to a peripheral neuropathy.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.